Effects of HMME-SDT on hypertrophic scar of rabbit ear
10.3760/cma.j.issn.1671-0290.2014.01.016
- VernacularTitle:血卟啉单甲醚声动力疗法对兔耳增生性瘢痕的疗效
- Author:
Wei LI
;
Jianfeng FEI
;
Xiaofeng LI
;
Zhiwei QU
;
Jiaqi BI
;
Yong CHENG
;
Qinggang MENG
- Publication Type:Journal Article
- Keywords:
Sonodynamic therapy (SDT);
Hematoporphyrinmonomethyl ether (HMME);
Hypertrophic scar
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2014;20(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of HMME-SDT therapy for the treatment of hypertrophic scar (HS) of rabbit ear.Methods 60 white rabbits were randomly divided into five groups.The model group and HMME-SDT treatment group were used to establish the models of hypertrophic scar in ears.Results The effect of HMME-SDT on the fibroblastic density in the hypertrophic scarring models was observed in rabbit ears.The HMME-SDT could lower the fibroblastic density,compared with the model group,with significant difference (P＜ 0.05).The effect of HMME-SDT on the collagen area density was noted in the hypertrophic scarring models in rabbit ears.The HMME-SDT could lower the collagen area density,compared with the model group,with significant difference from the fourth week of the epithelialization (P＜0.01).Conclusions HMME is an effective sonosensitizer.HMME-SDT can significantly inhibit hypertrophic scar of rabbit ear.
