The role of fibrin related markers in the diagnosis and prognosis of thrombosis
10.3760/cma.j.issn.1009-9158.2014.03.018
- VernacularTitle:纤维蛋白相关标志物在诊断和预防中的联合应用
- Author:
Jian LI
- Publication Type:Journal Article
- Keywords:
Disseminated intravascular coagulation;
Fibrin;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2014;37(3):233-235
- CountryChina
- Language:Chinese
-
Abstract:
Fibrin related markers include several proteins and fragments developed in the conversion of fibrinogen to cross-linked fibrin and following degradation.FDP played as a more important role than conventional global coagulation test before application of D-dimer in clinical settings,moreover,combination of FDP and D-dimer improve the diagnostic of DIC greatly,and D-dimer has become an effective tool excluding venous thromboembolism besides the imaging.Whether basic or clinical research on soluble fibrin monomers and complexes were focused in an early stage,however,limited by diversity of analytes and nonstandardization,no full application was come into being.It is worthwhile to note that fibrin related markers release into plasma sequentially from initialization of fibrinogen activation to fibrinolysis.Thus,the combination of these index is useful to understand patient's condition (such as DIC),prognosis of VTE recurrence,and prophylaxes of post-operation thrombosis.
