Role of microparticles in thrombotic diseases
10.3760/cma.j.issn.1009-9158.2014.03.002
- VernacularTitle:微粒在血栓性疾病中的作用
- Author:
Xiaomin XIN
- Publication Type:Journal Article
- Keywords:
Microparticles;
Phosphatidylserines;
Thrombosis;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2014;37(3):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Circulating microparticles (MPs) derive from a variety of cells,including platelets,leukocytes,endothelial cells and erythrocytes.In addition,tumor cells release MPs into blood.MPs are formed as a result of membrane lipid remodeling and proteolytic cleavage of cytoskeleton.Exposure of phosphatidylserine (PS) and tissue factor (TF) provide a surface for the assembly of Xase and prothrombianse to activate coagulation and induce thrombosis.Considerable levels of platelet-derived PS+ MPs are detected in healthy subjects.However,the level of PS+ and TF+ MPs,the latter of which predominantly derived from monocytes,greatly increased in thrombotic diseases,such as sepsis,cancer,and myocardial infarction.Therefore,MPs could be a useful biomarker for the evaluation of thrombosis risk.
