The value of biliary tumor markers for differentiatial diagnosis of benign and malignant biliary diseases
10.3760/cma.j.issn.1007-5232.2014.01.006
- VernacularTitle:探讨胆汁肿瘤标志物对胆管良恶性疾病的诊断价值
- Author:
Lixin TANG
;
Xu REN
;
Lingling ZHANG
;
Xiufen TANG
;
Chunlan ZHU
;
Yongping QU
- Publication Type:Journal Article
- Keywords:
Bile duct stricture;
Benign and malignant;
Bile;
Tumor markers;
Cholangiopancreatography,Endoscopic Retrograde
- From:
Chinese Journal of Digestive Endoscopy
2014;31(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of biliary tumor markers for differential diagnosis of the benign and malignant biliary tract diseases.Methods Tumor markers (CA19-9,CEA and CA242) examination and bacterial culture were performed in a total of 160 patients,who underwent therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for biliary diseases.Resuts There were significant differences between malignant group and benign group in bile and serum in the level of CA19-9,CEA and CA242 (P ＜0.05) ; Cut-off value,according to ROC curve,was 239 ku/l in CA19-9,40 ng/ml in CEA and 60 ku/ml in CA242,respectively.There were significant differences between the bile marker and the serum marker in sensitivity,accuracy,negative predicative value of CEA (P ＜ 0.05).No significant differences was found in specificity between the serum group and the bile group.There were significant differences in bile CA19-9 level between cholangiocarcinoma,pancreatic cancer,duodenal papilla carcinoma with carcinoma metastasizing to bile duct,and hepatocellular carcinoma (P ＜ 0.05).Both in benign group and malignant group,there were significant differences in CA19-9 level between infectious bile and noninfectious bile (P ＜ 0.05).Conclusion The level of CA19-9,CEA and CA242 in bile can be applied to differentiate benign and malignant biliary diseases.The bile tumor markers do not have advantage over serum tumor markers in specificity for diagnosis.Bile bacterial infection can result in the elevation of bile CA19-9 while it does not have impact on differential diagnosis.
