Expression and significance of KL-6 mucin in the bile and serum in differential diagnosis of benign and malignant obstructive jaundice
10.3760/cma.j.issn.1007-5232.2014.01.005
- VernacularTitle:胆汁和血清KL-6黏蛋白在良恶性梗阻性黄疸中的表达及临床意义
- Author:
Yang SHEN
;
Bing HU
;
Daojian GAO
;
Jun WU
;
Mingming ZHANG
;
Yingfeng ZHANG
;
Hongzhan ZHANG
- Publication Type:Journal Article
- Keywords:
Jaundice,Obstructive;
Bile;
KL-6 mucin;
Differential diagnosis
- From:
Chinese Journal of Digestive Endoscopy
2014;31(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of KL-6 mucin in differential diagnosis of benign and malignant obstructive jaundice.Methods A total of 41 patients with malignant tumors and 15 with benign lesions were recruited in the study.KL-6 mucin levels of bile and serum were measured using enzyme-linked immunosorbent assay (ELISA).The serum alpha-fetoprotein (AFP),carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels were also measured using radioimmunoassay (RIA).All data were analyzed by Mann-Whitney U test and Receiver Operating Characteristics (ROC)curves.Results CEA,CA19-9,and KL-6 mucin in serum and KL-6 mucin in bile in patients with malignant tumors were significantly higher than those in patients with benign lesions (P ＜ 0.001).There were no significant differences in serum AFP between the two groups.An receiver operating characteristic (ROC)curves analysis revealed that the detection of KL-6 mucin in bile was reasonably accurate in differentiating malignant obstructive jaundice from benign (area under curve [AUC] 0.954).While the AUC of the ROC curves for serum AFP,CEA,CA19-9,KL-6 mucin and KL-6 in bile and 0.954 were 0.657,0.753,0.894,0.846 and 0.954 respectively.Using the ideal threshold as the cut-off point,the sensitivity and specificity of KL-6 mucin for differential diagnosis of benign and malignant obstructive jaundice was 90.24％and 93.33％.Conclusion As a tumor marker,KL-6 mucin in bile is valuable in differential diagnosis of benign and malignant obstructive jaundice.
