Influence of trifluoromethylhydroartemisinin on chromosomes of mice
- Author:
Truong Van Nhu
- Publication Type:Journal Article
- Keywords:
trifluoromethylhydroartemisinin, chromosome
- MeSH:
Chromosomes;
Mice;
artemisinins
- From:Journal of Malaria and parasite diseases Control
2003;0(4):40-44
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Investigating the influence of trifluoromethylhydroartemisinin (BB.101) on chromosome mutations of mice. Mices were divided into 4 batches (B1, B2, B3 were dosed with BB.101 50mg/kg/day x 5 days, once, twice and thrice, respectively; each treatment course was repeated with 7 days intervals. B4 (control) were tested with arabic gum emulsion 1%). The results showed that: BB.101 were found not to increase frequency of confused chromosome in bone marrow cells of mices. Cells with confused structures and trouble clusters as crushed and smudged chromosomes were not found. BB.101 with the same dose was found not to increase frequency of confused chromosome in testicle cells of mices
