Discussion on ethical issues in experimental rats of fentanyl combined with midazolam in anesthesia
10.3760/cma.j.issn.1006-1924.2014.01.002
- VernacularTitle:芬太尼联合咪唑安定在实验大鼠麻醉中的伦理问题探讨
- Author:
Chengdong JI
;
Xuhui ZOU
;
Ming ZHU
;
Chang XU
;
Kan ZHANG
- Publication Type:Journal Article
- Keywords:
fentanyl;
midazolam;
combination;
therapy;
anesthesia;
ethics experimental rats
- From:
Chinese Journal of Medical Science Research Management
2014;27(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the mechanism of fentanyl combines midazolam,by comparison with some of the commonly used anesthetic method to determine in the ethical advantages of anesthesia.Methods 45 rats were randomly divided into three groups,Group A:1％ anesthetized by intraperitoneal injection of sodium pentobarbital 40 mg/kg; Group B:5 ％ ketamine 120 mg/kg intraperitoneal injection; Group C:midazolam 5 mg/kg + fentanyl 0.05 mg/kg Last intravenous anesthesia.Observe the effects of anesthesia.Results The rats which are used of fentanyl conbines midazolam anesthesia,the onset of anesthesia time:0.02 ± 0.03 min,maintenance of anesthesia time:89.73 ± 22.59 min,the the narcotic operation time:1.51 ± 0.30 min,the success of anesthesia cases:15 cases.Conclusions Fentanyl combines midazolam compared with the currently used method of anesthesia,the advantages of the more prominent,it has significant improvement and protection about the security,utilization and recovery ethics in experimental rats.
