Factors associated with anti-HBs titers in patients with hepatitis B diseases in the early stage following liver transplantation
10.3760/cma.j.issn.0254-1785.2014.03.007
- VernacularTitle:乙型肝炎患者肝移植后早期抗HBs滴度的影响因素分析
- Author:
Kai WANG
;
Zhijun ZHU
;
Hong ZHENG
;
Yonglin DENG
;
Cheng PAN
;
Liying SUN
;
Zhongyang SHEN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Hepatitis B surface antibodies
- From:
Chinese Journal of Organ Transplantation
2014;35(3):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the changes of anti-HBs titers of patients with hepatitis B virus (HBV)-related diseases in the early stage (within the first week) post-liver transplantation (LT) and analyze their influencing factors.Method A total of 26 patients were enrolled in this study.They were all positive for HBsAg pre-LT and received the prophylaxis of lamivudine in combination with intravenous hepatitis B immunoglobulin (HBIG) in the first week post-LT.The titers of anti-HBs were detected daily in blood and drainage fluid every day in the first week post-LT.If the anti-HBs titers were greater than 1000 IU/L,blood and drainage were diluted,then detected again.Result The titers of anti-HBs in HBV-DNA negative groups,low HBsAg groups,and HBeAg negative groups were higher than those in the HBV-DNA positive groups,high HBsAg groups and HBeAg positive groups in the first five days post-LT.The median titer of anti-HBs in drainage fluid was 181.60 IU/L (0.00-968.50 IU/L).And the titer of anti-HBs in drainage fluid was correlated with anti-HBs titers in blood at the same time (r =0.927,P =0.000).The amount of anit-HBs calculated in drainage fluid was very high,but it fluctuated in a wide range (0.00-908.55 IU).Conclusion In the early stage post-LT,patients in high risk groups should receive higher doses of HBIG to maintain safe levels of anti-HBs,while the lower doses of HBIG are enough to the patients in low risk groups.Furthermore,the anti-HBs titers in blood aren't affected by the anti-HBs loss in drainage fluid.
