Effect of vascular endothelial growth factor expression on prognosis of patients with liver transplantation for hepatocellular carcinoma
10.3760/cma.j.issn.0254-1785.2014.03.006
- VernacularTitle:血管内皮生长因子的表达对肝癌患者肝移植预后的影响
- Author:
Yan XIE
;
Wentao JIANG
;
Qingjun GUO
;
Nan MA
;
Honghai WANG
;
Dazhi TIAN
;
Cheng PAN
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Liver transplantation;
Vascular endothelial growth factors;
Prognosis
- From:
Chinese Journal of Organ Transplantation
2014;35(3):149-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of VEGF positive expression in tumor tissue in the prognosis of liver transplantation for hepatocellular carcinoma (HCC).Method Fifty cases of liver transplant recipients with HCC confirmed immunohistochemically were enrolled in this study.The MaxVisionTM two-step method was applied to detect the expression of vascular endothelial growth factor(VEGF),and the microvessel density (MVD) was measured in para-cancerous tissues by using DAB staining.The correlation of the VEGF tumor tissue in tumor tissue with Child-Pugh,MELD,tumor diameter and number,differentiation,MVD,Milan criteria and UCSF criteria for HCC liver transplantation was analyzed.Result In the HCC tissue,the VEGF positive expression rate was 52％(26/50).The one-year survival of recipients positive and negative for VEGF was 78％ and 100％,respectively,and one-year recurrence rate was 32％ and 12％,respectively,with the difference being significant (P =0.043 and P =0.048 respectively).The expression of VEGF was associated with Child-Pugh,tumor diameter,MVD,Milan criteria and UCSF criteria (P＜0.05 for all).Logistic regression analysis showed that low differentiation and VEGF positive expression were independent prognostic factors for HCC recurrence after liver transplantation.Conclusion VEGF has a certain reference value to judge HCC invasiveness and prognosis of liver transplantation.
