Effect of tacrolimus on blood lipid after renal transplantation and association of G protein beta 3 subunit (GNB3) gene C825T polymorphism to serum lipid levels
10.3760/cma.j.issn.0254-1785.2014.03.001
- VernacularTitle:他克莫司对肾移植受者血脂的影响及其与GNB3基因C825T多态性的相关性研究
- Author:
Chunzao WU
;
Yirong YANG
;
Xiaodong PAN
;
Yong GUO
;
Xiaojie NI
;
Xianbin SUN
;
Peng XIA
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Tacrolimus;
Hypercholesterolemia;
Hypertriglyceridemia
- From:
Chinese Journal of Organ Transplantation
2014;35(3):129-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Tacrolimus on blood lipid after renal transplantation,and the relationship between C825T polymorphism in G protein beta 3 subunit (GNB3) gene and serum lipid levels.Method Eighty-one cases of recipients patients after renal transplantation were divided into two groups in terms of Tacrolimus concentration:normal blood concentration group (group A) and low blood concentration group (group B).The serum lipid levels at 1st,3rd,6th,and 12th month after renal transplantation were measured.Genotype was determined by the simple sequence-specific primer polymerase chain reaction (SSP-PCR).Result The percentage of patients with hypertriglyceride in group A was significantly higher than in group B during the one-year follow-up period.There was significant difference between the two groups in the serum triglyceride levels but no difference in the serum cholesterol levels.The 825C/T polymorphism in the GNB3 gene was not associated with hypertriglyceride in renal transplantations in Wenzhou.Conclusion The serum triglyceride levels in renal transplantations in Wenzhou was associated with the Tacrolimus concentration,and the incidence of hypertriglyceride is not associated with the 825C/T polymorphism in the GNB3 gene.
