The analysis of risk factors in gastrointestinal graft versus host disease following allogeneic hematopoietic stem cell transplantation

VernacularTitle:异基因造血干细胞移植后胃肠道移植物抗宿主病的危险因素分析
Author: Jun GUAN ; Youshan ZHANG ; Jinhuan XU ; Jin YIN ; Yang CAO ; Yicheng ZHANG
Publication Type:Journal Article
Keywords: Hematopoietic stem cell transplantation; Graft versus host disease; Risk factor
From: Chinese Journal of Organ Transplantation 2014;35(1):17-20
CountryChina
Language:Chinese
Abstract: Objective To investigate the risk factors of gastrointestinal graft versus host disease(GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT).Method 214 patients receiving allo-HSCT from 2003 to 2012 were enrolled in this study,and assessed on the degree of gastrointestinal GVHD.The effects of the primary diseases status,gender,age,conditioning regimen intensity,donor type,the number of cells positive for the CD34 expression,and the use of anti-lymphocyte immunoglobulin (ALG) in the pretreatment scheme on the occurrence of gastrointestinal GVHD was studied.The responses of different degrees of GVHD to immunotherapy were evaluated.Result Univariate and multivariate analyses revealed that the graft type and the conditioning regimen intensity were the risk factors of gastrointestinal GVHD (P＜0.05).Conclusion Donor type and conditioningregimen intensity may be the main risk factors of gastrointestinal GVHD.