The development of nanobody probes for molecular imaging
10.3760/cma.j.issn.2095-2848.2014.01.023
- VernacularTitle:纳米抗体用于分子影像的研究进展
- Author:
Zhiling DING
;
Xiaoli LAN
;
Yongxue ZHANG
- Publication Type:Journal Article
- Keywords:
Nanotechnology;
Antibodies;
Molecular imaging;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014;34(1):68-72
- CountryChina
- Language:Chinese
-
Abstract:
The nanobody is a novel antibody fragment,which has beneficial biophysical and pharmacokinetic properties,such as the small molecular weight,high affinity and specificity for antigen.Nanobody is ideally suitable for molecular imaging as a targeting probe that could label antigen at nmol level in vitro.In animal models of xenografted tumor,atherosclerotic plaques and brain disorders,the target tissues were specifically and clearly detected and the high tumor-to-blood (T/B) ratios were obtained.Structural or chemical modified nanobodies will have higher affinity and retention to target tissues,and be convenient for the application of molecular imaging.With the development of the related research,nanobody-based molecular imaging will be gradually transformed into the clinical applications,and play an important role in early diagnosis and therapeutic assessment.
