Moderate hypofractionated image-guided thoracic radiotherapy for locally advanced node-positive non-small cell lung cancer patients with very limited lung function: a case report.
- Author:
Farkhad MANAPOV
1
;
Olarn ROENGVORAPHOJ
;
Minglun LI
;
Chukwuka EZE
Author Information
- Publication Type:Case Report
- Keywords: Hypofractionated radiotherapy; Image-guided radiotherapy; NSCLC; Thoracic radiotherapy
- MeSH: Carcinoma, Non-Small-Cell Lung*; Electrons; Four-Dimensional Computed Tomography; Humans; Induction Chemotherapy; Lung Neoplasms; Lung*; Lymph Nodes; Palliative Care; Prognosis; Radiotherapy*; Radiotherapy, Image-Guided; Tumor Burden
- From:Radiation Oncology Journal 2017;35(2):180-184
- CountryRepublic of Korea
- Language:English
- Abstract: Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second [FEV1] ≤ 1 L) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes. Planning was based on positron emission tomography-computed tomography (PET/ CT) and four-dimensional computed tomography (4D-CT). Internal target volume (ITV) was defined as the overlap of gross tumor volume delineated on 10 phases of 4D-CT. ITV to planning target volume margin was 5 mm in all directions. Both patients showed good clinical and radiological response. No relevant toxicity was documented. Hypo-IGRT is feasible treatment option in locally advanced node-positive NSCLC patients with very limited lung function (FEV1 ≤ 1 L).
