Relationship between positive peritoneal exfoliated cancer cells and the clinicopathological features in patients with hepatocellular carcinoma: a retrospective study of ninety-two patients

VernacularTitle:原发性肝细胞癌92例患者腹腔脱落癌细胞阳性率分析
Author: Xiaofen YU ; Zaiyuan YE ; Yingyu MA ; Qinfang ZHANG ; Xianqin HU
Publication Type:Journal Article
Keywords: Hepatocellular carcinoma; Exfoliated cancer cell; Peritoneal effusion ascites; Peritoneal lavage fluid
From: Chinese Journal of Hepatobiliary Surgery 2014;20(1):20-23
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between positive peritoneal exfoliated cancer cells and the clinicopathological features of patients with hepatocellular carcinoma before any invasive treatment.Methods Of the 92 patients with hepatocellular carcinoma who underwent laparotomy,ascites fluid was collected in the patients with peritoneal ascites; and peritoneal lavage fluid was collected in those patients without peritoneal ascites.Then,shedded cancer cells in these fluid samples were detected.Results The positive rates of peritoneal cancer cells were associated with the TNM stage,tumor location and tumor size.The positive detection rate of cancer cells in TNM stage Ⅲ and Ⅳ was significantly higher than stage Ⅰ and Ⅱ (38.1％ vs 8.0％ ; P =0.0005).The positive detection rate was higher in tumors located closer to the surface (P =0.0 002),and with larger diameter (P =0.00 007).Conclusion Peritoneal cancer cells were significantly correlated with tumor stage,tumor location and size in hepatocellular carcinoma.