The expression and significance of survivin in hepatocellular carcinoma: a Meta-analysis
10.3760/cma.j.issn.1007-8118.2014.02.010
- VernacularTitle:Survivin蛋白在肝细胞癌组织中表达及其意义的Meta分析
- Author:
Chaoyi REN
;
Yijun WANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Survivin;
Meta-analysis
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(2):113-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of survivin in hepatocellular carcinoma(HCC).Methods All reports published in the past 13 years on survivin and hepatocellular carcinoma (HCC) were reviewed.A Meta-analysis was conducted on these studies and it was used to determine the prognostic significance of the expression of survivin on patients with HCC.Results 18 studies were included into this Meta-analysis.There were 1 021 HCC patients and 208 normal controls.There was a significant difference between the positive rate of survivin in hepatocellular carcinoma and in normal tissues (0R =30.61; 95％ CI:16.67-56.23).The expression of survivin correlated with clinical staging,pathological differentiation,tumor metastasis,portal vein tumor thmmbus,and survival (P ＜ 0.05).There was no correlation with gender,age,AFP,HBsAg,tumor diameter,and tumor capsule (P ＞ 0.05).Conclusiom Survivin can be used as a molecular marker for the definitive prognosis of HCC.It is also a reliable marker in the choice of standardized and individualized therapy.
