The relationship between Gly587Arg variant of COX-2 gene and the primary liver cancer
10.3760/cma.j.issn.1008-6315.2014.02.009
- VernacularTitle:环氧化酶2基因Gly587Arg多态与原发性肝癌发病风险的相关性
- Author:
Guangxia WANG
;
Zhanzhao FU
;
Shasha SHAO
;
Qinqin SONG
;
Juan RAO
;
Yingwen LIU
;
Zhi ZHANG
- Publication Type:Journal Article
- Keywords:
Primary liver cancer;
Cyclooxygenase 2;
Single nucleotide polymorphism;
Genotyping
- From:
Clinical Medicine of China
2014;30(2):141-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of COX-2 Gly587Arg polymorphism with the risk of primary liver cancer.Methods Two hundred and seventy patients with primary liver cancer and 540 health people were selected as our subjects.DNA were extracted from peripheral blood lymphocytes,and genotypes were measured by polymerase chain reaction-restriction fragment length polymorphism method.Odds ratios(OR) and 95％ confidence intervals(CI) were estimated by logistic regression.Results Two kinds of genotype (587Gly/ Gly and Gly/Arg) were found in all participants.No one carried 587Arg/Arg genotype.Among primary liver cancer patients,91.5％ (247/270,) 8.5％ (23/270) of individuals carried 587Gly/Arg and Gly/Arg genotype,which was significantly higher than that of controls (96.5％ (521/540,) 3.5％ (19/540)).Multivariate Logistic regression analysis showed that individual carried 587Gly/Arg genotype had an increased risk of developing primary liver cancer (OR =2.56,95％ CI =1.37-4.79,P =0.003) compared with 587Gly/Gly carriers.Conclusion COX-2 Gly587Arg polymorphism is a risk factor for primary liver cancer in Han.
