Clinical significance of the serum transforming growth facto-1,interleukin-10,interferon-γ in of patients with hepatic fibrosis
10.3760/cma.j.issn.1008-6315.2014.01.013
- VernacularTitle:乙型肝炎肝纤维化患者血清转化生长因子1、白细胞介素10及干扰素γ的表达及临床意义
- Author:
Haili GAO
;
Hongwei WANG
;
Daokun YANG
;
Xinwei WANG
;
Quanchu WANG
- Publication Type:Journal Article
- Keywords:
Hepatic fibrosis;
Transforming growth factor-β1;
interleukin-10;
Interferon-γ
- From:
Clinical Medicine of China
2014;30(1):41-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum transforming growth factor-β1 (TGF-β1),interleukin-10(IL-10) and interferon-γ(INF-γ) in elderly patients with hepatic fibrosis and their correlation with hepatic fibrosis.Methods One hundred and thirty-three patients diagnosed by pathological hepatic tissue were enrolled as case group who were in the first affiliated hospital of Xinxiang Medical University from 2007 to 2013.The enzyme-linked immunosorbent assay (ELISA) was applied to detect of serum levels of TGF-β1,IL-10and IFN-γ.Meanwhile 21 healthy people were recruited as control group.Results Comparison with the control group,the levels of TGF-β1 and IL-10 were significantly higher(TGF-β1:(217.4 ± 7.5) ng/L vs.(57.2±4.8) ng/L,t =15.61,P＜0.01;IL-10:(29.6 ±3.2) ng/L vs.(15.1 ±7.5) ng/L,t =11.44,P＜0.01),while IFN-γlevel was lower ((51.9 ± 3.5) ng/L vs.(75.8 ± 5.9) ng/L,P =0.03) in case group.The serum levels of TGF-β1,IL-10,IFN-γand stages of hepatic fibrosis was correlated and the correlation coefficients were 0.786,0.644 and-0.822 respectively (P ＜ 0.05).Conclusion Serum levels of TGF-β1,IL-10 and IFN-γ in patients with hepatic fibrosis are proved to be with ability of predicting the development of hepatic fibrosis and the post treatment.
