Predictive value of plasma atrial natriuretic peptide level in prognostic evaluation of patients with Sepsis
10.3760/cma.j.issn.1008-6315.2014.03.011
- VernacularTitle:动态监测心房钠尿肽对脓毒症患者预后的评估价值
- Author:
Qing LI
;
Yue LIU
;
Bin GENG
;
Jinjin LI
- Publication Type:Journal Article
- Keywords:
Atrial natriuretic peptide;
Sepsis;
Prognostic evaluation
- From:
Clinical Medicine of China
2014;30(3):257-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predictive value of plasma atrial natriuretic peptide (ANP) level on prognostic of patients with systemic inflammatory response syndrome by dynamic monitoring ANP levels.Methods Ninety-eight patients admitted to the intensive care unite were classified into survival group(n =78) and death group (n =20).The level of plasma ANP,procalcitonin,C-reactive protein and lactic acid were measured.Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score were recorded.Results The plasma ANP level of patients in the death group was 0.40 (0.26) μg/L,significantly higher than that in the survival group(0.22(0.12) μg/L,P =0.000).Along with treatment scheme,the plasma ANP level decreased in survival group,and there were significant difference among three times (0.22 (0.12) μg/L,0.17 (0.09) μg/L,0.13 (0.11) μg/L,P =0.000).But there was no difference in ANP level of patients in death group along with the disease developing (0.38 (0.30) μg/L,0.39 (0.23) μg/L,0.39 (0.22) μg/L,P =0.99).ICU hospitalized time in survive group associated with APACHE Ⅱ score,ANP and PCT(r =0.735,0.628,0.487 respectively,P =0.000,0.001,0.021).Conclusion ANP is proved to be a good clinical index in prognostic evaluation of patients with sepsis.
