The characteristic analysis on intestinal metabolism of Pueraria lobata (Willd.)Ohwi
10.3760/cma.j.issn.1673-4246.2014.02.010
- VernacularTitle:口服葛根的肠代谢特征分析
- Author:
Hewei LI
;
Tong ZHAO
;
Ling DONG
;
Gang WANG
;
Honghuan DONG
;
Yanjiang QIAO
- Publication Type:Journal Article
- Keywords:
Radix Puerariae;
Flos Puerariae;
S9;
Intestinal metabolism
- From:
International Journal of Traditional Chinese Medicine
2014;36(2):131-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method to compare the difference of exposure component of oral taking different part ofPueraria Lobata (Willd.) Ohwi in intestine.Methods After the incubation of puerarin,extraction Radix Puerariae and Flos Puerariae with S9,the mixtures were centrifuged to get the supernatant for analysis with HPLC.Results The research showed that the metabolic rate of puerarin was higher than that of extractions because of the concentration of enzyme.The difference between the fingerprints of Radix Puerariae and Flos Puerariae Lobata indicated that there was a difference of chemical components in such two parts of Kudzuvine Root.Conclusion The profile of intestinal metabolism can be revealed in the research of gut wall metabolism in the course of intestinal absorption by S9 incubation.
