Progress on antitumor effects of zoledronic acid in breast cancer

VernacularTitle:唑来膦酸在乳腺癌中抗肿瘤作用的研究现状
Author: Chen CHEN ; Weili SUN ; Jia CHEN ; Jiege HUO
Publication Type:Journal Article
Keywords: Antineoplastic agents; Breast neoplasms; Zoledronic acid
From: Journal of International Oncology 2014;41(3):196-199
CountryChina
Language:Chinese
Abstract: As the third-generation bisphosphonate,zoledronic acid (ZOL) has been widely used for the treatment of skeletal-related events in breast cancer.Previous studies have demonstrated that ZOL has antitumor activitie in breast cancer.ZOL can induce direct and indirect antitumor activities through inducing apoptosis,inhibiting the proliferation,adhesion and invasion formation of bone microenvironment which is conducive to tumor growth,besides inhibiting angiogensis and modulating immune response.Also evidences of synergistic antitumor effects are found when ZOL combines with radiotherapy and chemotherapy,endocrine,and targeted drugs.The observed improvement in antitumor effects by using combination therapy with ZOL in breast cancer is currently being verified through additional clinical trials.