Advances in signal transduction pathway regulating EMT in tumor invasion and metastasis
10.3760/cma.j.issn.1673-422X.2014.03.004
- VernacularTitle:信号通路调控上皮间质转化参与肿瘤侵袭转移的分子机制
- Author:
Lei ZHU
;
Hua SUI
;
Wanli DENG
- Publication Type:Journal Article
- Keywords:
Neoplasm invasiveness;
Neoplasm metastasis;
Epithelial-mesenchymal transition
- From:
Journal of International Oncology
2014;41(3):172-177
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) is a differentiation process of epithelial cells into mesenchymals,which is widespread in the invasion and metastasis of malignant tumor.Studies show that EMT is influenced by a variety of factors such as cytokines,signaling pathways and transcription factors.Studies also show that intracellular and extracellular signal transmission could induce EMT.Signal transduction is a process which involves ligand-receptor binding in the extracellular,going into the cell and activating different nuclear transduction factor through intracellular signal transduction pathway.
