Role of calcium signaling in neoplasms invasion and migration
10.3760/cma.j.issn.1673-422X.2014.03.001
- VernacularTitle:钙信号在恶性肿瘤侵袭迁移中的作用
- Author:
Meng ZHU
;
Xuejun YANG
- Publication Type:Journal Article
- Keywords:
Calcium signaling;
Neoplasm invasiveness;
Neoplasm metastasis
- From:
Journal of International Oncology
2014;41(3):161-164
- CountryChina
- Language:Chinese
-
Abstract:
Intracellular calcium is one of the crucial signalings that modulate various physiological and pathological processes.Abnormal calcium signaling is closely associated with invasion and migration of neoplasms.Calcium regulates focal adhesion turnover,cytoskeletal reorganization and other processes about tumor cell movement through contacting with multiple downstream proteins,such as calpain,PYK2 and S100 protein family.Several calcium entry channels including store-operated calcium channels and transient receptor potential channels participate in the invasion and migration of tumor cells.Pathological calcium signaling may be a potential target in anti-invasion and anti-migration therapy.
