Study on pharmacokinetics of PSD-007 in BN rats by fluorescence detection methods
10.3760/cma.j.issn.1673-4181.2014.01.004
- VernacularTitle:荧光光谱法测定癌光啉在BN大鼠体内的药代动力学
- Author:
Huijuan YIN
;
Hongli CHEN
;
Lichao GU
;
Yingxin LI
- Publication Type:Journal Article
- Keywords:
PSD-007;
BN rat;
Fluorescent spectrometry;
Pharmacokinetics
- From:
International Journal of Biomedical Engineering
2014;37(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacokinetic characteristics of PSD-007 in BN rats.Methods Blood of the BN rats was collected from the inner canthus after iv administration of PSD-007,and the plasma drug concentrations at different times were determined by fluorescent spectrometry.The best compartment model and the pharmacolinetic were calculated by the software of DNS 2.0.Results The elimination process of PSD-007 fitted three-compartment open model after iv administration.The principal pharmacokinetic parameters were t1/2α=0.096 h,t1/2β=1.299 h,t12γ=19.387 h,V1=0.259 L/kg,A UC=15.263 mg/(L ·h).Conclusions The sensitivity of fluorescent spectrometry was high and the operation is sinple and the progress is short.PSD-007 has fast absorption,quick effect and elimination without accumulation phenomenon.
