Research progress of calcification and anti-calcification of implanted silicone rubber
10.3760/cma.j.issn.1673-4181.2014.01.013
- VernacularTitle:外科植入硅橡胶材料钙化及抗钙化研究进展
- Author:
Shuping SHI
;
Xing WU
- Publication Type:Journal Article
- Keywords:
Biomaterials;
Silicone rubber;
Complications;
Calcification;
Anti-calcification
- From:
International Journal of Biomedical Engineering
2014;37(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Calcification of silicone rubber is a pathologic mineralization phenomenon which occurs on the surface after it is implanted in vivo,and there is no effective prevention method.The important process of calcification including these steps:phosphate ions combined with calcium ions to promote nucleating aggregation,slow increasing,fusion,and gradually form a larger accumulation of hydroxyapatite calcium.The research had been developed to the level of cells and genes,such as matrix Gla protein clusters is a calcification inhibitor of the tissues around silastic prosthesis.It is necessary to obtain a theoretical breakthrough in the aspect of organic template modulation of inorganic crystals.Silicone elastomer having its own local anti-calcification property had been paid more attention.Fully revealing the mechanism of calcification and calcification-resistant of silicone rubber will probably provide the basis for building a new anti-calcification material.
