Correlation between serum cystatin C and intima-media thickness of carotid artery in patients with hypertension

VernacularTitle:高血压患者胱抑素C与颈动脉内膜中层厚度的关系
Author: Xia LI ; Chunyuan HAO ; Manli CHENG ; Yuqiang JI ; Gang TIAN
Publication Type:Journal Article
Keywords: Hypertension; Cystatin C; Intima-media thickness of carotid artery
From: Chinese Journal of Postgraduates of Medicine 2014;37(7):46-48
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation between cystatin C (Cys C) and intima-media thickness of carotid artery (CIMT) in patients with hypertension.Methods One hundred and one patients with hypertension (hypertension group) and 54 healthy people (control group) were enrolled in this study.The level of serum Cys C was measured and CIMT was detected by B ultrasound.The correlation between Cys C and CIMT was analyzed.Results The level of Cys C and CIMT in hypertension group were significantly higher than those in control group [(0.92 ±0.21) mg/L vs.(0.85 ±0.20) mg/L,(0.91 ±0.16) mm vs.(0.65 ± 0.15) mm] (P ＜ 0.05 or ＜ 0.01).Multiple linear correlation analysis showed that Cys C and CIMT was positively correlated in total population or hypertension group or control group (r =0.412,0.443,0.315,P ＜0.01).Conclusion Serum Cys C is associated with the degree of hypertension arteriosclerosis,and Cys C may be involved in atherosclerosis.