Clinical efficacy of itraconazole combined with glucocorticosteroid in allergic bronchopulmonary aspergillosis
10.3760/cma.j.issn.1673-4904.2014.04.002
- VernacularTitle:伊曲康唑联合糖皮质激素治疗变态反应性支气管肺曲霉菌病的疗效分析
- Author:
Fan LIU
;
Ran ZHU
;
Delei KONG
;
Chenye FENG
;
Tingwei LIU
;
Jian KANG
- Publication Type:Journal Article
- Keywords:
Aspergillosis,allergic bronchopulmonary;
Itraconazole;
Glucocorticoids
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(4):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of itraconazole combined with glucocorticosteroid in allergic bronchopulmonary aspergillosis.Methods The clinical characteristics and data of 11 allergic bronchopulmonary aspergillosis patients treated with itraconazole combined with glucocorticosteroid were retrospectively collected before treatment and two months after treatment.Then the clinical characteristics and data before and after treatment were compared to evaluate the efficacy of the treatment.Results The symptoms and signs got better after two months' treatment.C reactive protein,IgE and eosinophile granulocyte count after two months' treatment were significantly lower than that before treatment [(7 ±2) mg/L vs.(42± 13) mg/L,(742 ± 236) kU/L vs.(1 685 ±477) kU/L,(343 ± 112) × 106/L vs.(1 925 ± 318) × 106/L],and forced expired volume in one second percentage of predicted and arterial partial pressure of oxygen after two months' treatment were significantly higher than those before treatment [(77.5 ± 8.6)％ vs.(32.4 ± 9.1)％ and (81 ± 12) mmHg (1 mmHg =0.133 kPa) vs.(53 ± 6) mmHg],there were statistical differences (P ＜ 0.01 or ＜ 0.05).The inflammatory exudates resolved as demonstrated in pulmonary CT scan.Conclnsion Itraconazole combined with glucocorticosteroid can effectively neat allergic bronchopulmonary aspergillosis.
