Relationship between D-dimer levels and disseminated intravascular coagulation in septic shock patients
10.3760/cma.j.issn.1673-4904.2014.03.005
- VernacularTitle:感染性休克患者D-二聚体水平的变化与弥散性血管内凝血的关系
- Author:
Qimao LIU
- Publication Type:Journal Article
- Keywords:
Septic shock;
D-dimer;
Disseminated intravascular coagulation
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(3):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between D-dimer levels and disseminated intravascular coagulation(DIC) in septic shock patients.Methods A total of 188 patients with septic shock were divided into DIC group (36 cases) and non-DIC group(152 cases).Serum D-dimer of the patients was detected by automatic latex particle enhanced immunoturhidimetric assay,serum D-dimer cutoff value was calculated by receiver operating characteristics (ROC) curve.Results There was no significant difference in serum D-dimer after 1 d shock between DIC group and non-DIC gorup [(1258.69 ± 296.34) mg/L vs.(1108.45 ± 226.23) mg/L,P ＞ 0.05].Serum D-dimer after 3,5,7 d shock in DIC group was higher than that in non-DIC group [(1468.95 ±448.78) mg/L vs.(967.76 ±214.32) mg/L,(1702.12 ±578.40) mg/L vs.(886.57 ± 187.22) mg/L,(1924.21 ±796.76) mg/L vs.(821.46 ± 178.32) mg/L],there was significant difference (P ＜0.05).Serum D-dimer cutoff value was 303 mg/L,calculating by ROC curve,and on condition of serum D-dimer ≥1203 μg/L,the sensitivity that judged the DIC occurrence rate after septic shock was 81.5％ and specificity was 76.3％.Conclusions Serum D-dimer changes of the patients with septic shock not only relate to the patient's disease severity,but also have a close relationship to whether DIC happen.Therefore,determination of serum levels of D-dimer in patients with septic shock has important clinical significance to the diagnosis and prognosis.
