Effects of Radix Hedysari Flavonoid on Microvessel Density of Pulmonary Interstitial Fibrosis Model Rats
10.3969/j.issn.1005-5304.2014.04.014
- VernacularTitle:红芪黄酮对肺间质纤维化模型大鼠微血管密度的影响
- Author:
Yali SHE
;
Yun SU
;
Yi ZHANG
;
Juan LI
;
Yongqi LIU
;
Xiaoli CHENG
;
Xingyao LIN
;
Jintian LI
- Publication Type:Journal Article
- Keywords:
pulmonary fibrosis;
Radix Hedysari flavonoids;
microvessel density;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(4):43-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effects of Radix Hedysari flavonoids on microvessel density (MVD) of pulmonary interstitial fibrosis model rats, and provide evidence for its development. Methods SPF Wistar rats were divided into blank group, model group, prednisone group, and Radix Hedysari flavonoids high-, medium- and low-dosage group. Pulmonary interstitial fibrosis model was established by intratracheal instillation of bleomycin. From the second day after model established, each drug treatment group was administered with corresponding drugs intragastrically at different points in time for 14 and 28 days. MVD was detected by immunohistochemistry. Results Neomicrovessel was increased significantly in pulmonary tissue of model rats of 14 days treatment, but slightly decreased in 28 days. MVD in 14, 28 days model group was significantly more than blank group (P<0.01). MVD in 14, 28 days Radix Hedysari flavonoids high dosage group was significantly less than model group (P<0.01). MVD in Radix Hedysari flavonoids medium-dosage group was between high-and low-dosage group, and MVD in medium-dosage group was similar with that in model group. Conclusion Radix Hedysari flavonoids could inhibit the formation of neomicrovessel in a dose dependent manner.
