Clinical Study on Shaoyaozhitong Mixture in Treatment of Stage Ⅲ-Ⅳ Endometriosis
10.3969/j.issn.1005-5304.2014.04.009
- VernacularTitle:芍药止痛合剂治疗Ⅲ～Ⅳ期子宫内膜异位症临床研究
- Author:
Jinbang XU
;
Danmei LIN
;
Qiaoyan LIN
;
Hailong HUANG
;
Chaobin LIU
;
Junying JIANG
;
Yuanjun CAI
- Publication Type:Journal Article
- Keywords:
endometriosis;
Shaoyaozhitong Mixture;
GnRHa;
traditional Chinese medicine therapy;
clinical effect
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(4):26-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Shaoyaozhitong Mixture on stageⅢ-Ⅳendometriosis, and explore its mechanism. Methods Ninty-five cases of stageⅢ-Ⅳ endometriosis were randomly divided into three groups. The traditional Chinese medicine (TCM) group (31 cases) was treated with Shaoyaozhitong Mixture, the GnRHa group (31 cases) was treated with Triptorelin Acetate for Injection, while the expectant group (33 cases) received no medications. The changes of CA125, TNF-α and VEGF levels, visual pain score and SF-36 score, total effective rate, pregnancy and recurrence were compared. Results There were significant increases in CA125, TNF-α and VEGF levels, visual analogue pain score and SF-36 score in all the three groups after treatment (P<0.05). The decline of CA125, TNF-αand VEGF levels and visual analogue pain score in TCM group and GnRHa group was significantly faster and greater than that of the expectant group (P<0.05). The total effective rates of TCM group was 83.9%(26/31), GnRHa group was 87.1%(27/31), and expectant group was 60.6%(20/33), TCM group and GnRHa group were superior to the expectant group, respectively (P<0.05). The pregnancy rate was higher and recurrence rate was lower in TCM group and GnRHa group than that of expectant group, but there was no statistical difference (P>0.05). Conclusion Shaoyaozhitong Mixture is effective in treating endometriosis by inhibiting the growth of ectopic endometrium.
