Clinical and immunological features of 45 children with lupus nephritis

VernacularTitle:儿童狼疮性肾炎45例临床、病理及免疫学分析
Author: Xueqin CHENG ; Huaying BAO ; Aihua ZHANG ; Guixia DING ; Fei ZHAO
Publication Type:Journal Article
Keywords: lupus nephritis; clinical manifestations; pathology; immunological feature; child
From: Journal of Clinical Pediatrics 2014;(3):246-249
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical and immunological features of 45 pediatric patients with lupus nephritis (LN). Methods Forty-five LN patients were included in this study. Clinical, pathological data and immunological parameters were retrospectively analyzed. Results Forty-five LN patients had 6 males and 39 females, with the mean onset age of (10.9 ± 2.8) years. Acute nephritis was the most common type, accounting for 42.2%. Nephrotic syndrome accounted for 31.1%. Renal biopsy showed class II (17.8%), III (4.4%), IV (48.9%), V (2.2%), V+III (6.7%)and V+IV (13.3%)in 42 cases. The remis-sion rate reached 91.1%in the early therapeutic stage, and 15.0%patients recurred after 24-month follow-up. Conclusions The clinical manifestations of LN children are diverse. The renal pathology is complex. The clinical manifestations in part of the chil-dren are not consistent with renal pathology.