Changes and clinical significance of CGRP and IL-1 αbefore and after warm acupuncture therapy in patients with lumbar disc herniation

VernacularTitle:腰椎间盘突出症患者温针治疗前后血清CGRP及IL-1α的变化及临床意义
Author: Xinguo FENG ; Xiaobin LI ; Jianliang YI ; Fan YANG ; Xiaomin LIU
Publication Type:Journal Article
Keywords: enzyme-linked immunosorbent assay; calcitonin gene-related peptide; interleukin 1α
From: International Journal of Laboratory Medicine 2014;(5):521-522
CountryChina
Language:Chinese
Abstract: Objective To investigate the changes and clinical significance of calcitonin gene related peptide (CGRP) and interleu-kin 1α(IL-1α) before and after warm acupuncture therapy in the patients with lumbar disc herniation (LDH ) .Methods Serum CGRP and IL-1αcontents were detected before and after the warm acupuncture therapy in 60 cases of lumbar disc herniation and 15 healthy control cases by ELISA method for conducting the statistical analysis .The changes of the McGill pain scores and serum CGRP and IL-1αconcentrations before and after the warm acupuncture therapy were observed .Results The McGill pain scores af-ter the warm acupuncture therapy in the LDH patients were significantly decreased ,the difference was statistically significant (P<0 .01) ,and serum CGRP and IL-1α concentrations were significantly decreased ,the difference was statistically significant (P<0 .01) .Conclusion CGRP and IL-1αcan be used as the observation index of the effects for the warm acupuncture therapy in trea-ting LDH ,which can provide the basis for the conservative treatment of LDH .