Analysis of pathogen distribution and antibiotic resistance in 1606 blood cultures from neonates
10.3969/j.issn.1000-3606.2014.03.003
- VernacularTitle:1606例新生儿败血症病原菌分布及其耐药性分析
- Author:
Xiaojuan TANG
;
Xing FENG
- Publication Type:Journal Article
- Keywords:
neonatal septicemia;
blood culture;
antibiotic resistance
- From:
Journal of Clinical Pediatrics
2014;(3):210-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the pathogen profile and antibiotic resistance in aerobic isolates from blood cultures of neonates. Methods All blood culture reports (n=28120) from newborns admitted to the Department of Neonatology during 2002-2012 were analyzed, and the sensitivity patterns were recorded. Results A total of 1665 bacteria were isolated from 1606 blood culture-positive samples and the positive rate of blood cultures was 5.7%(1606/28120). Gram-positive bacteria were iso-lated in 1336 cases, with Staphylococcus epidermidis (902 cases) and Staphylococcus haemolyticus (206 cases) being the com-mon bacteria. Klebsiella pneumoniae (108 cases), followed by Escherichia coli (73 cases), were the major Gram-negative bacte-ria (235 cases). The determination of the antibiotic resistance of aerobic isolates was performed in 2012. Most Gram-positive iso-lates were sensitive to vancomycin and moxifloxacin, and more than 90%were resistant to penicillin while most of Gram-nega-tive isolates were sensitive to amikacin and imipenem. Conclusions Staphylococcus epidermidis, Staphylococcus haemolyticus, Klebsiella pneumoniae and Escherichia coli remain to be the principal organisms responsible for neonatal sepsis.
