Role of plasma (1-3)-beta glucan D testing in curative effect evaluation of pulmonary fungal infection
10.3969/j.issn.1673-4130.2014.05.003
- VernacularTitle:血浆（1-3）-β-D葡聚糖检测在肺部真菌感染疗效评价中的作用
- Author:
Yongping XIE
;
Guomei LI
;
Jieran WEN
;
Xueling TANG
;
Xiuhong LUN
;
Yaoju TAN
;
Meiyu PAN
;
Weinan YE
- Publication Type:Journal Article
- Keywords:
beta-glucans;
lung diseases,fungal;
antifungal agents
- From:
International Journal of Laboratory Medicine
2014;(5):517-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic change and the clinical curative effect evaluation of plasma (1-3)-beta glucan D (BG) in the patients with pulmonary disease complicating fungal infection .Methods The MB-80 miroorganism dynamic rapid de-tection system and fungi BG detection kits were adopted to detect plasma BG content before and after treatment in 87 cases of pul-monary disease complicating fungal infection and the controls .The sputum culture in the patients was performed before and after treatment .Results Plasma BG levels before antifungal therapy ,at 1 ,2 weeks after treatment in 87 patients were (162 .81 ± 70 .03) , (15 .89 ± 30 .88) and (4 .58 ± 7 .87)pg/mL ,which in the control group was (5 .62 ± 1 .83)pg/mL ,plasma BG level had statistical differences between before treatment and at 1 ,2 weeks after treatment in the patients with the control group (P<0 .05);Plasma BG levels between at 1 week after treatment with at 2 weeks after treatment and the control group had statistically significant differ-ences (P<0 .05) .Among 87 patients ,66 cases were positive sputum culture at 1 week after antifungal drug treatment and 9 cases were positive sputum culture at 2 weeks after treatment .Conclusion Continuously monitoring the patient′s plasma BG level com-bined with the sputum fungal culture results ,clinical symptoms and lung shadow in X-ray has certain clinical value to judge the anti-fungal effect .
