Effect of Panax Notoginseng Saponins on Cerebral Water Content and Thrombin of Intracerebral Hemorrhage Rats
10.3969/j.issn.1005-5304.2014.02.013
- VernacularTitle:三七总皂苷对脑出血大鼠脑含水量和凝血酶的影响
- Author:
Xuesong ZHAO
;
Zhigang CHEN
;
Fang GAO
;
Zhifang XU
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
Panax notoginseng saponins;
cerebral water content;
thrombin;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(2):46-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Panax notoginseng saponins (PNS) on the cerebral water content and thrombin in the rats with intracerebral hemorrhage (ICH), and explore its mechnism for treating ICH. Methods SD male rats were randomly divided into blank group, sham operation group, model group and treatment group, and time points of 6, 24, 48, 72 h and 7 d were observed. ICH rat model was induced by collagenase and heparin in saline solution injected into caudate nucleus. The treatment group was injected PNS intraperitoneally once a day, and the cerebral water content was assessed by dry-wet weight method. Both content of fibrinogen (FIB) and thrombin clotting time (TT) in 48 h were measured. Results The cerebral water content of model group increased at every time point compared with blank group and sham operation group (P<0.05). The cerebral water content of treatment group was significantly decreased at every time point except for 6 h compared with model group (P<0.05). FIB of treatment group decreased compared with model group (P<0.05), while TT of treatment group was not significantly decreased (P>0.05). Conclusion PNS may play a role in treating ICH by decreasing cerebral water content, FIB and TT of ICH rats.
