Antibacterial Activity of Alkaloids Extract from Oxytropis falcata Bunge Against 9 Pathogens
10.3969/j.issn.1005-5304.2014.02.015
- VernacularTitle:镰形棘豆生物碱对临床9种致病菌的抑制作用研究
- Author:
Hua JIANG
;
Junru HU
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
Oxytropis falcata Bunge;
alkaloids extract;
pathogens;
antibacterial activity
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(2):53-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antibacterial activity of the alkaloids extract from Oxytropis falcata Bunge against 9 common pathogens in vitro. Methods Alkaloids was extracted from Oxytropis falcata Bunge. The agar plate dilution method was adopted to evaluate the activity against bacteria of 4 Gram-negative test strains and 5 Gram-positive test strains, while the MIC and MBC were determined by tube double dilution method. Results The alkaloids extract from Oxytropis falcata Bunge had the antibacterial activity against 9 pathogens and there was a good dose-response relationship between sensitivity and concentration. Antibacterial activities against bacillus subtilis and stentrophmomas maltophilia showed stronger than other tested bacteria, the MIC and MBC were 0.95 mg/mL and 1.91 mg/mL, respectively. In other tested bacteria, MIC and MBC were ranged in 1.91-7.63 mg/mL. Conclusion The alkaloids extract showed a broad spectrum of a stronger antibacterial activity against all tested pathogens. Gram-positive strains were more sensitive than Gram-negative strains to the inhibitory effects of the alkaloids extract.
