Evaluation of Removing Pyrogen Effect of Activated Carbon in Traditional Chinese Medicine Injection Technics
10.3969/j.issn.1005-5304.2014.02.023
- VernacularTitle:中药注射剂工艺中活性炭除热原效果评价
- Author:
Wenchun LI
;
Yonghui SUN
;
Renhai CUI
;
Rao FU
;
Changxin LI
;
Liwen XIE
;
Yingxin WANG
- Publication Type:Journal Article
- Keywords:
pyrogen;
activated carbon;
traditional Chinese medicine injection;
Shuanghuanglian powders for injection;
Danshen for injection (freeze-dried)
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(2):80-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the pyrogen removing effect of activated carbon in the technics of traditional Chinese medicine (TCM) injections. Methods The content of bacterial endotoxin concentration was detected by kinetic turdimetric assay to evaluate the effect of removing pyrogen before and after using activated carbon in concentrated solution of TCM injection. Results The activated carbon adsorption rate of Shuanghuanglian concentrated solution≥70%and the activated carbon adsorption rate of Danshen concentrated solution>95%. Conclusion Pyrogen manufacturing process is scientific and rational by adding activated carbon adsorption in powder injection of TCM. The bacterial endotoxin of large doses can't be removed fully by activated carbon adsorption.
