In Vitro Dissolution Feature of Chuangxiong Powder
10.3969/j.issn.1005-5304.2014.02.026
- VernacularTitle:川芎散剂体外溶出特征研究
- Author:
Yang LIU
;
Beiran LV
;
Baosheng ZHAO
;
Guopeng WANG
;
Xiaoyan HAN
;
Lei ZHANG
;
Honghuan DONG
;
Meiling ZHU
;
Li WEI
;
Mingmin TANG
- Publication Type:Journal Article
- Keywords:
Chuanxiong;
ferulic acid;
dissolution;
UV spectrophotometry;
Weibull model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(2):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the dissolution of Chuangxiong powder in different medium and discuss the dissolution characteristics in vitro of Changxiong powder. Methods The paddle method was adopted, the UV spectrophotometric method was developed to determine the in vitro dissolution quantity of Changxiong powder in five medium (water, 0.1 mol/L hydrochloric acid, acetate buffer of pH 4.5, phosphate buffer of pH 6.8, phosphate buffer of pH 7.4) with ferulic acid as index, and evaluated by drawing the dissolution curve and using the similar factor method and Weibull model. Results The dissolution quantity of Changxiong oral powder in five medium was different. The dissolution quantity in water, 0.1 mol/L hydrochloric acid, acetate buffer of pH 4.5 and phosphate buffer of pH 6.8 was similar and fit Weibull model, but it mutated in phosphate buffer of pH 7.4 and reached the maximum amount at 30 min. Conclusion The dissolution quantity of Changxiong powder is gradually increasing and the time is shorted in the medium from acidic to neutral then to alkaline. Dissolution curve is similar in the acidic and neutral medium. Changxiong powder dissolves out fast and completely in the alkaline medium.
