Influencing Factors of Recurrence and Metastasis for Postoperative Breast Cancer High-risk Population and Evaluation on TCM Therapy
10.3969/j.issn.1005-5304.2014.02.008
- VernacularTitle:乳腺癌术后高危人群复发转移影响因素及中医治疗评价
- Author:
Qi FU
;
Lin SHI
;
Guowang YANG
;
Xiaomin WANG
- Publication Type:Journal Article
- Keywords:
postoperative breast cancer;
high-risk population;
recurrence and metastasis;
influencing factors;
traditional Chinese medicine therapy
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(2):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influencing factors of recurrence and metastasis for postoperative breast cancer high-risk population, and TCM regimen of syndrome differentiation and treatment was used to validate its significance for the prevention of recurrence and metastasis. Methods The influencing factors of recurrence and metastasis of 178 postoperative breast cancer high-risk cases with positive hormone receptor were studied. The recurrence and metastasis, disease-free survival and accumulative points of TCM symptoms of integrated group (with TCM syndrome differentiation and endocrine therapy) and western medicine group (with endocrine therapy) were compared. Results Lymph node metastasis, cancer staging and TCM therapy had influence on the disease-free survival rate of postoperative breast cancer high-risk patients. TCM therapy was the independent prognostic factor for disease-free survival. 3-year recurrence and metastasis rate was lower in integrated group than that in western medicine group, with statistical difference (P=0.03). The total accumulative points of TCM symptoms in both two groups decreased after treated for 3 and 6 months, integrated group showed greater significance. TCM therapy was better for the treatment of irritability, hot flash and perspiration, good for spontaneous perspiration and insomnia, but poor in dry mouth, bitter taste in mouth and fatigue. Conclusion Lymph node metastasis, cancer staging and TCM therapy are main influencing factors for recurrence and metastasis. TCM therapy with regimen of syndrome differentiation and treatment can reduce 3-year recurrence and metastasis rate, improve TCM symptoms, especially is significant for the improvement of irritability, hot flash and perspiration.
