Single Institutional Experiences of Insulinoma.
- Author:
Sun Hyuck LEE
1
;
Chang Moo KANG
;
Jun Young KIM
;
Gi Hong CHOI
;
Kyung Sik KIM
;
Jin Sub CHOI
;
Woo Jung LEE
;
Byong Ro KIM
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. wjlee@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Neuroendocrine neoplasm;
Pancreas;
Insulinoma
- MeSH:
Diagnosis;
Humans;
Insulinoma*;
Male;
Multiple Endocrine Neoplasia Type 1;
Natural History;
Neck;
Pancreas;
Pancreatectomy;
Prognosis;
Retrospective Studies;
Splenectomy;
Ultrasonography
- From:Journal of the Korean Surgical Society
2007;72(2):128-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We present our experiences of pancreatic insulinoma among the functioning neuroendocrine neoplasm of the pancreas, to review the natural history and suggest proper management. METHODS: From June 1990 to August 2006, patients with diagnosis of pancreatic insulinoma were retrospectively reviewed. RESULTS: Thirteen patients (5 men and 8 women) with median age of 42 years (range, 12~68 years) were investigated. One patient (12%) with pancreatic insulinoma was MEN 1. Intraoperative ultrasound scan (sensitivity, 88%) was the most powerful modality for tumor localization. Sixteen neoplasms with median tumor size 1 cm (range, 0~3 cm) were found. Ten neoplasm (62%) were located in the heads/ necks of the pancreas. Six neoplasm (38%) were located in the tails. Five neoplasm (31%) were located around the neck areas near the SMV or PV. Twelve patients (92%) underwent enucleation, and two patients (15%) underwent distal pancreatectomy with splenectomy. 100% of patients with pancreatic insulinoma have survived and the overall disease free 10-year survival was found to be about 85.7%. CONCLUSION: Exact localization of tumor by intraoperative ultrasound and effective surgical removal can be significantly beneficial for good prognosis.
