Effects of epimedium on osteogenic differentiation of bone marrow mesenchymal stem cells
10.3969/j.issn.2095-4344.2014.06.026
- VernacularTitle:淫羊藿对骨髓间充质干细胞成骨分化的影响
- Author:
Huizhen LI
;
Meng LI
;
Ruiyu LI
;
Liping WU
- Publication Type:Journal Article
- Keywords:
stem cells;
mesenchymal stem cells;
myeloid progenitor cells;
mesenchymal stem celltransplantation;
drugs,Chinese herbal;
medicine,Chinese traditional
- From:
Chinese Journal of Tissue Engineering Research
2014;(6):979-984
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Epimedium has been used in the treatment of osteoporosis and repair of bone defects. OBJECTIVE:To explore the effects of epimedium on the osteogenic differentiation of bone marrow mesenchymal stem cells.
METHODS:A database search was performed to retrieve literatures addressing epimedium effects on the osteogenic differentiation of bone marrow mesenchymal stem cells. Then, the papers meeting the criteria were selected for in-depth analysis. During the osteogenic differentiation induced by epimedium, alkaline phosphatase, osteocalcin, osteopontin, transforming growth factorβ, bone morphogenetic proteins, osteocalcin, bone sialoprotein were detected in the bone marrow mesenchymal stem cells to understand the underlying mechanism of epimedium in proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.
RESULTS AND CONCLUSION:Epimedium effects on bone marrow mesenchymal stem cells are shown in a dose-dependent manner. During the early induction, icari n can increase cellphosphatase activity;in the late induction, icari n can increase calcified nodules, promote osteocalcin secretion, significantly improve the expressions of transforming growth factorβ1, bone morphogenetic protein 2, insulin-like growth factor-1, osteopontin and bone sialoprotein. Epimedium, which can be used as an excellent osteoinductive factor, improves the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.
