Correlation between cervical lesion development and histone acetylation modification that regulates RAR-β2 expression
10.3969/j.issn.1000-8179.20131140
- VernacularTitle:组蛋白乙酰化修饰调控RAR-β2表达与宫颈病变的相关性
- Author:
Jiaojiao WU
;
Dingqing FENG
;
Yuan TIAN
;
Hanjie XU
;
Bing LI
;
Bin LING
- Publication Type:Journal Article
- Keywords:
histone acetylation modification;
RAR-β2;
cervical intraepithelial neoplasia;
squamous cell cervical carcinoma;
differ-entiation
- From:
Chinese Journal of Clinical Oncology
2014;(5):300-304
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between cervical lesion development and histone acetylation that regulates RAR-β2 expression. Methods:Immunohistochemistry and Western blot analysis were performed to detect AcH3, RAR-β2, and involu-crin expression in normal cervical tissues as well as in tissues with cervical intraepithelial neoplasia (CIN)Ⅱ-Ⅲand squamous cell cer-vical carcinoma. The relationship among histone acetylation level, RAR-β2 expression, and cervical lesion severity were analyzed. Re-sults:AcH3, RAR-β2, and involucrin expression were reduced or absent with the progression of cervical lesions;significant differences were noted between the groups (P<0.05). Histone acetylation level and RAR-β2 expression were positively correlated (r=0.797, P<0.05). AcH3 and RAR-β2 expression, which were both associated with the cervical lesions, were negatively correlated [r=-0.547(AcH3), r=-0.585(RAR-β2), P<0.05]. Conclusion:Histone acetylation modification is associated with the regulation of RAR-β2 expression. This pro-cess is also likely to participate in the carcinogenesis of cervical carcinoma.
