The correlation of 18F-fluoroestradiol uptake in patients with breast cancer to in vitro immunohistochemical assay of ER status

VernacularTitle:18F-FES在乳腺癌患者体内摄取与病理免疫组化的关系
Author: Yifei SUN ; Zhongyi YANG ; Yongping ZHANG ; Mingwei WANG ; Zhifeng YAO ; Jing XUE ; Xiao BAO ; Wentao YANG ; Zhenzhou SHEN ; Zhimin SHAO ; Yingjian ZHANG
Publication Type:Journal Article
Keywords: Estrogen receptor; Immunohistochemistry; 18F-FES; 18F-FDG; ER subtype
From:China Oncology 2014;(2):128-134
CountryChina
Language:Chinese
Abstract: Background and purpose:16α-[18F]lfuoroestradiol (18F-FES) is an in vivo speciifc imaging agent for estrogen receptor (ER). We investigated the concordance between tumor ER status as determined by FES-PET and in vitro immunohistochemical assays. Methods: 18F-FES was prepared by ourselves. Twenty-six patients were enrolled (17 primary and 9 metastatic/recurrent). Patients underwent both 18F-FES and 18F-FDG PET/CT. Results:We found good overall agreement (96.15%) between in vitro ER assays and FES-PET. The ER status diagnosis sensitivity of 18F-FES was 93.33%and the speciifcity was 100%when using cut-off value of SUVmax≥1.5. There was a positive correlation between in vitro ER, PR assays and the SUVmax of 18F-FES while in vitro HER-2/neu assays correlatived negatively with 18F-FES SUVmax. Conclusion:These results suggested 18F-FES may be useful for studying the ER expression of all malignant lesions in patients with breast cancer and guiding individual therapy.