Expression and significance of MMP-14 and EMMPRIN in human oral squamous cell carcinoma
- VernacularTitle:MMP-14与EMMPRIN在口腔鳞状细胞癌中的表达及临床意义
- Author:
Ye TAO
;
Lingda ZHANG
- Publication Type:Journal Article
- Keywords:
oral squamous cell carcinoma;
reverse transcription-polymerase chain reaction;
MMP-14;
EMMPRIN
- From:
Acta Universitatis Medicinalis Anhui
2014;(1):81-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of MMP-14 and EMMPRIN and the correlation between them in oral squamous cell carcinoma ( OSCC) . Methods The expression of MMP-14 and EMMPRIN mR-NA in 43 cases of OSCC and 11 cases of normal oral tissue were detected by RT-PCR. Results The expression of MMP-14 and EMMPRIN mRNA in OSCC was significantly higher than those in normal oral tissue ( P <0.05 ) . Compared with those without lymph node metastasis in OSCC, the expression of MMP-14 and EMMPRIN mRNA with lymph node metastasis was significantly higher ( P <0.05 ) . Furthermore, the expression of MMP-14 and EMMPRIN was significantly associated with pathological stage and the lymph node metastasis,but neither of them was correlated with sex and age. Correlation analysis showed that MMP-14 expression level was positively related to EMMPRIN level(r=0.801,P<0.01). Conclusion The expression of MMP-14 and EMMPRIN in OSCC is signif-icantly correlated with occurrence, progress and metastasis of OSCC. Therefore, the combination of detecting the expression of MMP-14 and EMMPRIN mRNA may evaluate the degree of malignancy and predict the prognosis of patients with OSCC.
