Correlation between the estrogen replacement therapy and the prevalence of female with Alzheimer's dis-ease:a meta-analysis
10.3936/j.issn.1002-0152.2014.01.002
- VernacularTitle:雌激素替代疗法与女性阿尔茨海默病关系的Meta分析
- Author:
Zhen LV
;
Qunan WANG
;
Min WEI
- Publication Type:Journal Article
- Keywords:
Estrogen replacement therapy;
Alzheimer's disease;
Meta-analysis
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between estrogen replacement therapy and female patients with Alzheimer's risk. Methods We searched the PubMed, Springer, CBM, CNKI, VIP database for studies on the es-trogen replacement therapy and women with Alzheimer's disease, retrieval time from database to 2012 December. We evaluated the methodological quality of the included studies, used RevMan 5.0 software to analyze the extracted data. Results We found seven case-control studies which included 1392 patients and 2719 controls. The meta analysis re-sults show that the proportion of estrogen replacement therapy in AD group is significantly lower than that of the con-trol group, the difference has statistically significant [OR=0.68, 95%CI(0.50,0.90), P=0.01]. Conclusions estrogen re-placement therapy has effects on female patients with Alzheimer's disease, and is a protective factor.
