Efficacy analysis of Jin Long Capsule (JLC) in neoadjuvant chemotherapy of breast cancer
10.3969/j.issn.1000-8179.20130104
- VernacularTitle:金龙胶囊在乳腺癌新辅助化疗中的疗效分析
- Author:
Junwen BAI
;
Wanmin WU
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
Combined treatment of Traditional Chinese and Western Medicine;
Traditional Chinese Medicine;
therapeutic effecacy;
adverse reactions
- From:
Chinese Journal of Clinical Oncology
2014;46(4):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the therapeutic efficacy and adverse reaction induced by Jin Long Capsule (JLC) combined with TEC regimen (docetaxel+epirubicin+cyclophosphamide) in neoadjuvant chemotherapy of breast cancer. Methods:A total of 64 patients who had stagesⅡtoⅢbreast cancer were divided into two groups randomly:JLC combined with neoadjuvant chemotherapy group (JLC group, n=32) and conventional neoadjuvant chemotherapy group (control group, n=32). The chemotherapy cycle was 21 d equal-ly. Evaluations of therapeutic effects were made after three cycles of neoadjuvant chemotherapy and consequent operation. Results:The effective powers (complete response+partial response) of the JLC group and the control group were 84.38% (27/32 cases) and 56.25%(18/32 cases), respectively. The difference was statistically significant (P<0.05). The main adverse effects were gradesⅡtoⅢgastrointestinal tract indisposition and myelosuppression. WBC decrease and incidence rate of nausea and vomiting were obviously low-er in the JLC group than in the control group (P<0.05). The life quality of patients in the JLC group was greatly improved than that in the control group (P<0.05). Conclusion:The application of JLC combined with neoadjuvant chemotherapy can improve therapeutic ef-ficacy and reduce the poisonous side effects of chemotherapy, thereby improving the life quality of patients.
