Advances in oncolytic adenovirus-loaded mesenchymal stem cells for treating tumors
10.3969/j.issn.1000-8179.20121860
- VernacularTitle:间质干细胞荷载溶瘤腺病毒治疗肿瘤进展
- Author:
Chunhua YANG
;
Lijun MAO
- Publication Type:Journal Article
- Keywords:
oncolytic adenovirus;
mesenchymal stem cells;
neoplasms
- From:
Chinese Journal of Clinical Oncology
2014;46(4):266-268
- CountryChina
- Language:Chinese
-
Abstract:
Oncolytic adenoviruses have been used in cancer gene therapy because of their ability to selectively transfect and repli-cate in tumor cells. However, systemically administering oncolytic adenoviruses is often inefficient because the host's immunity also at-tacks the viruses. Delivering oncolytic adenoviruses by loading them into mesenchymal stem cells effectively solves this problem. Mes-enchymal stem cells have been described to possess a tumor-homing ability, as well as the capacity to deliver oncolytic adenoviruses. This review discusses the current challenges faced by oncolytic adenovirus delivery via mesenchymal stem cells.
