Alginate-chitosan microcapsule in tissue engineering research
10.3969/j.issn.2095-4344.2014.03.014
- VernacularTitle:海藻酸钠-壳聚糖微胶囊载体在组织工程研究中的应用
- Author:
Hengli JIANG
;
Yuanlu CUI
;
Xuejie QI
;
Yun QI
;
Shu DING
- Publication Type:Journal Article
- Keywords:
biocompatible materials;
review;
chitosan;
capsules
- From:
Chinese Journal of Tissue Engineering Research
2014;(3):412-419
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Alginate-chitosan microcapsule can improve the mechanical property of sodium alginate hydrogels. How to obtain the ideal sodium alginate-chitosan microcapsule and the prospect for application of the microcapsule system is the key to this study.
OBJECTIVE:To investigate the preparation method and formation mechanism of alginate-chitosan microcapsules, to analyze several important factors affecting the strength of the microcapsule membrane, and to explore the prospects of alginate-chitosan microcapsules in immobilized celltechnology, in tissue engineering and as a drug carrier.
METHODS:The first author searched PubMed, Elsevier ScienceDirect, CNKI and Wanfang database (1987/2013) to retrieve literatures about the preparation method, formation mechanism and application prospect of alginate-chitosan microcapsules.
RESULTS AND CONCLUSION:Sodium alginate hydrogels have many advantages in drug release and tissue engineering, but its application is limited by gel dissolution phenomena and deficiencies in its mechanical properties. Chitosan-alginate microcapsules make up for the deficiency of sodium alginate hydrogels by electrostatic interactions to form polyelectrolyte complexes. By control ing the nature of the chitosan solution--the molecular weight of chitosan, pH and concentration of chitosan solution, we can prepare the microcapsules with high film strength. Alginate-chitosan microcapsules have shown broad application prospects in immobilization technology, drug release and tissue engineering.
