Study on General Pharmacology of Grape Seed Proanthocyanidin Extract
10.3969/j.issn.1005-5304.2014.03.011
- VernacularTitle:葡萄籽提取物原花青素一般药理学研究
- Author:
Huicong CHEN
;
Jianying ZHAI
;
Guangping ZHANG
;
Xiaoguang ZHU
;
Hairun YANG
;
Siyu ZHANG
;
Wei JIANG
;
Jinsheng LI
- Publication Type:Journal Article
- Keywords:
grape seed proanthocyanidin extract;
Chinese drug pharmacology;
cardiovascular system;
respiratory system;
central nervous system;
dogs;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(3):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influences of grape seed proanthocyanidin extract (GSPE) on cardiovascular system, nervous system and respiratory system of experimental animals, and provide general pharmacological data for further research and application. Methods The influences of GSPE on blood pressure, heart rate, electrocardiogram, breathing frequency and tidal volume in anesthetic dogs after duodenal administration were observed, the impacts on spontaneous activity, coordinated motion, and the sleep situation with threshold dose and subthreshold dose of pentobarbital sodium in mice after intragastric administration were observed. Results GSPE showed no side effects on blood pressure, heart rate, electrocardiogram, breathing frequency and tidal volume in anesthetic dogs at the dosage of 857.00, 214.29, 42.86 mg/kg (P>0.05). At the dosage of 428.57, 214.29, 42.86 mg/kg, GSPE had no obvious influence on spontaneous activities and coordinated movements in mice (P>0.05). GSPE did not evidently change the number of sleeping animals, the sleep latency and the sleeping duration with subthreshold dose and threshold dose of pentobarbital sodium (P>0.05). Conclusion GSPE has no evident adverse effects on central nervous system, cardiovascular system and respiratory system in animals.
