Expression and clinical significance of CCNG2 in glioblastoma pa-tients
10.3969/j.issn.1000-8179.22013136
- VernacularTitle:CCNG2在神经胶质瘤组织中的表达及其临床意义
- Author:
Xianglong CHEN
;
Kefei HE
;
Xiaoting CHEN
- Publication Type:Journal Article
- Keywords:
glioblastoma;
CCNG2;
immunohistochemistry;
clinicopathologic parameters
- From:
Chinese Journal of Clinical Oncology
2014;46(4):237-241
- CountryChina
- Language:Chinese
-
Abstract:
Object:To investigate the expression of cell cyclin G2 (CCNG2) in glioblastoma tissues and to explore the correla-tion of CCNG2 expression with clinicopathological parameters and clinical significance. Methods:Surgical specimens of glioblastoma were collected from a total of 129 cases. The expression of CCNG2 in 109 specimens with complete clinical data was examined via QRT-PCR and immunohistochemistry. Results:The expression of CCNG2 was significantly decreased in higher stages of glioblastoma compared with those in lower stages. Therefore, CCNG2 is inversely correlated with the stage of the disease. The expression of CCNG2 was associated with tumor stage, sensitivity to chemotherapy and radiotherapy, as well as survival times (P<0.05). CCGN2 was not cor-related with gender and age (P>0.05). Conclusion: CCNG2 expression may be associated with the development, treatment efficacy, and prognosis of glioblastoma. In addition, CCGN2 can be used to evaluate the malignant behavior of glioblastoma.
