Syndrome of inappropriate anti-diuretic hormone in lung-cancer patients:six cases

VernacularTitle:肺癌合并抗利尿激素分泌不当综合症6例临床分析
Author: Dandan ZHU ; Daming ZHOU ; Lijing ZHANG
Publication Type:Journal Article
Keywords: lung neoplasms; inappropriate ADH syndrome; hyponatremia
From: Chinese Journal of Clinical Oncology 2014;46(4):259-261
CountryChina
Language:Chinese
Abstract: Objective:To investigate the clinical characteristics, treatment, and evaluation of the prognosis of syndrome of inap-propriate anti-diuretic hormone (SIADH) in lung-cancer patients. Methods:We review the clinical data of six lung cancer cases, includ-ing four small cell lung cancer, one adenocarcinoma, and one squamous cell carcinoma, with SIADH complication. All six cases were treated in our hospital over the past three years. Results:Patients with various serum sodium levels were provided different therapeutic regimens. Symptoms of fatigue and nervous system disorders, plasma sodium, urine sodium, and plasma osmotic pressure were alleviat-ed. Conclusion:SIADH is a common complication of lung cancer, particularly in small lung cancer cases. Electrolyte disturbances indi-cate poor prognosis, high mortality rate, and delay in treatment because of clinical interest. After a final diagnosis has been made and ap-propriate treatment has been administered, clinical symptoms were relieved and blood sodium levels were quickly and significantly im-proved in these patients.